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7-(DIETHYLAMINO)COUMARIN-3-CARBOXYLIC ACID ETHYL ESTER

7-(Diethylamino)coumarin-3-carboxylic acid ethyl ester (CAS 28705-46-6) is a classic high-performance fluorescent coumarin dye engineered for laser technologybioimaging applications, and optoelectronic materials research. This molecule integrates a 7-diethylaminocoumarin core—a privileged fluorophore scaffold renowned for high quantum yield, photostability, and tunable emission—with an ethyl ester substituent at the C3 position. The strong electron-donating diethylamino group at C7 coupled with the electron-withdrawing ester at C3 creates an efficient intramolecular charge transfer (ICT) system, resulting in bright blue-green fluorescence with excellent solvatochromic properties. The ethyl ester moiety provides enhanced lipophilicity compared to the free acid analog, facilitating membrane permeability for cellular imaging applications, while also serving as a synthetic handle for further derivatization via hydrolysis or transesterification. This intermediate is particularly valuable for constructing tunable laser dyesfluorescent probes for protein/DNA labelingFRET pair donors, and organic semiconductor materials where precise wavelength control and robust fluorescence performance are critical. Manufactured under controlled conditions, it supports research programs requiring reliable fluorescent standards with well-characterized photophysical properties.

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Product Name
7-(Diethylamino)coumarin-3-carboxylic acid ethyl ester
CAS Number
28705-46-6
Chinese Name
7-二乙氨基香豆素 -3-羧酸乙酯
Synonyms
Coumarin 3; Coumarin 3 ethyl ester; Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate; C₁₆H₁₉NO₄ fluorescent dye; Laser dye intermediate; CDEAC
Chinese Synonyms
乙基 7-二乙氨基 -2-氧代 -2H-色烯 -3-羧酸酯; 二乙氨基香豆素 -3-羧酸乙酯; 香豆素激光染料; 荧光标记中间体
Molecular Formula
C₁₆H₁₉NO₄
Molecular Weight
289.33 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Fine Chemicals / Fluorescent Dyes / Coumarin Derivatives
Appearance
Yellow to Orange Crystalline Powder
Melting Point
~150-155°C (literature reference recommended)
Excitation/Emission
λex ~400-430 nm, λem ~480-510 nm (solvent-dependent, estimated)
Quantum Yield
~0.7-0.9 in ethanol (estimated, literature reference recommended)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed in amber glass under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid fluorescence quenching.
Shelf Life
24 months under recommended storage conditions (monitor for photodegradation)
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
Tunable laser dye synthesis, fluorescent probe development, biological staining (protein/DNA/cellular), FRET pair donor design, OLED material precursor, solvatochromic sensor research, optoelectronic device fabrication
Reactivity
Suitable for ester hydrolysis to free acid, transesterification, electrophilic aromatic substitution at C6/C8, incorporation into polymer matrices, and solvent-dependent fluorescence tuning
Special Note
Classic ICT Fluorophore—strong donor-acceptor system enables bright blue-green emission. Ethyl ester enhances lipophilicity vs. free acid. Light-sensitive—store in amber containers to prevent photobleaching. Part of our fluorescent dye building block series.