Methyl 5-amino-1H-pyrazole-3-carboxylate

Methyl 5-amino-1H-pyrazole-3-carboxylate (CAS 632365-54-9) is a high-purity heterocyclic building block widely used in pharmaceutical intermediates and agrochemical synthesis. This functionalized pyrazole derivative features three orthogonal reactive sites: a C5-amino group for electrophilic substitution or cyclization, a C3-methyl ester for hydrolysis or amide coupling, and a 1H-pyrazole core—a privileged scaffold in modern drug discovery. The electron-rich pyrazole ring, combined with the activating amino substituent, enables regioselective functionalization at the C4 position, making it ideal for constructing complex heterocyclic architectures. Key applications include the synthesis of kinase inhibitors, pyrazolo[1,5-a]pyrimidine fused systems, and anti-inflammatory agents. With its combination of reactivity and stability, this intermediate supports medicinal chemistry programs, CNS modulator research, and prodrug design initiatives requiring nitrogen-rich heteroaromatic scaffolds. Manufactured under controlled conditions, it is available in multiple packaging sizes to meet R&D and commercial needs.