2-(Thiophen-3-yl)ethanol

2-(Thiophen-3-yl)ethanol (CAS 13781-67-4) is a strategically functionalized thiophene derivative engineered for pharmaceutical intermediate synthesis, ligand development, and materials science applications. This molecule integrates a 3-substituted thiophene core—a sulfur-containing five-membered heterocycle with excellent electron-donating properties and π-conjugation potential—with a 2-hydroxyethyl side chain at the C3 position. The primary alcohol terminus serves as a versatile handle for esterification, etherification, oxidation to aldehyde/acid, or conversion to halides for further cross-coupling strategies. The meta-like substitution pattern on the thiophene ring provides distinct electronic distribution compared to 2-substituted analogs, enabling unique binding orientations in target proteins. This intermediate is particularly valuable for constructing CNS-penetrant drug scaffolds, sulfur-containing ligands for metal coordination, and conductive polymer precursors where the thiophene-ethanol motif balances lipophilicity with synthetic flexibility. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to functionalized thiophene architectures with tunable physicochemical properties.